منابع مشابه
Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are frequently observed in lung adenocarcinoma (LUAD). We have previously shown that RBM10 enhances exon skipping of its target genes, including its paralog RBM5. Here, we report that RBM10 negatively regulates its own mRNA and protein expression and that of RBM5 by promoting alternative splicing-coupled nonsense-me...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملRbm20 regulates titin alternative splicing as a splicing repressor
Titin, a sarcomeric protein expressed primarily in striated muscles, is responsible for maintaining the structure and biomechanical properties of muscle cells. Cardiac titin undergoes developmental size reduction from 3.7 megadaltons in neonates to primarily 2.97 megadaltons in the adult. This size reduction results from gradually increased exon skipping between exons 50 and 219 of titin mRNA. ...
متن کاملMetabolic Signaling Regulates Alternative Splicing during Photomorphogenesis.
Alternative splicing (AS) regulates gene expression and greatly expands the coding capacity of complex genomes. By regulating which elements of an mRNA transcript are removed or retained, AS produces multiple transcripts from a single gene. Some of these transcripts contain a premature termination codon (PTC) and are targeted for degradation by nonsense-mediated mRNA decay (NMD; Kalyna et al., ...
متن کاملA Novel CDX2 Isoform Regulates Alternative Splicing
Gene expression is a dynamic and coordinated process coupling transcription with pre-mRNA processing. This regulation enables tissue-specific transcription factors to induce expression of specific transcripts that are subsequently amplified by alternative splicing allowing for increased proteome complexity and functional diversity. The intestine-specific transcription factor CDX2 regulates deve...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2014
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2014.01.052